Lipitor and Zocor are both pharmaceutical drugs for heart disease and cholesterol reduction. Lipitor is developed by Pfizer and is known as the best selling prescription medicine in the world, with over $12 billion USD in annual sales. Lipitor is used to treat high blood pressure and heart diseases that can lead to heart attack. Lipitor is also known as Torvast, Torvacard, Tulip, Totalip, Atorpic, Sortis, Xarator, and Liprimar in different countries and regions. Lipitor is known as a very effective medicine when combined with changes in diet, exercise and smoking.

Zocor is a prescription medicine for the reduction of cholesterol that is often marketed as a generic alternative to Lipitor. Zocor was developed from a different method of synthesis by the Merck Pharmaceutical Company. Zocor is also used to treat high blood pressure and heart diseases that can lead to heart attack. Zocor is also known as Zocord, Zimstat, Sivastin, Simvaxon Simvastatin-Teva, Simvacor, Simovil Sinvacor, Simvahexal, Liponorm, Lipovas, Lodales, Lipex, and Denan in other countries and regions.

Comparison chart

Lipitor

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Zocor

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Functions Reduces cholesterol and high blood pressure associated with heart disease. Reduces cholesterol and high blood pressure associated with heart disease and heart attacks
Effect Plasma concentrations occur within 1-2 hours Plasma concentrations peaked at 4 hours
Manufacturer Pfizer Merck
Prescription Required Required
Side Effects Both have minimal side effects including upset stomach, gas, heartburn, change of taste, diarrhea, constipation, skin rash, headache, dizziness or blurred vision that may occur the first few days as your body adjusts to the medication. Minimal side effects: upset stomach, gas, heartburn, change of taste, diarrhea, constipation, skin rash, headache, dizziness or blurred vision that may occur the first few days as your body adjusts to the medication
Generic Name Atorvastatin calcium Simvastatin
Dosage The recommended starting dose of Lipitor is 10 or 20 mg once daily The recommended usual starting dose is 10 mg once a day in the evening
Oral administration 10 mg, 20 mg, 40 mg, 80 mg 5 mg, 10 mg, 20 mg, 40 mg, 80 mg
Usage May be used in combination with a bile acid binding resin for additive effect Zocor is effective alone or when used concomitantly with bile-acid sequestrants
Legal status Prescription only Prescription Only
Routes Oral Oral
Physical Properties A white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water A white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol

Chemical differences between zocor and lipitor

Generically, Lipitor is called Atorvastatin calcium and its empirical formula is C33H34 FN2O5)2Ca•3H2O

with a molecular weight of 1209.42. Zocor, on the other hand is called Simvastatin with a empirical formula of C25H38O5 and a molecular weight of 418.57.

Physical properties of lipitor vs. zocor

Lipitor is white to off-white with crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Zocor is white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water.

Zocor and Lipitor are Prescribed For

Lipitor and Zocor both are taken to reduce high blood pressure caused by cholesterol and reduce the risk of heart attack and stroke for those with clogged arteries.

Since 2013, the American Heart Association and the American College of Cardiology have recommended that statin drugs like Zocor and Lipitor be prescribed to more at-risk individuals, including all people over 40 who have type 2 diabetes.

How zocor and lipitor work

Lipitor works to break down colesterol deposits that collect within the blood vessels of the body to reduce high blood pressure. If colesterol deposits develop in the blood vessels of the heart, they can cause a heart attack. Liptor is an alternative to angioplasty or blood thinning methods of blood pressure reduction. Lipitor uses a HMG-CoA reductase inhibitor to reduce Low Density Cholesterol. Liptor works by enzyme blocking. The drug blocks an enzyme in the liver that leads to the reduction of Low Density Cholesterol that can lead to a heart attack or stroke.

Zocor functions in a similar manner to dissolve cholesterol deposits within blood vessels that cause high blood pressure and heart attack. The patent on Zocor expired recently allowing for reduced cost generic versions of the drug. Some studies suggest Zocor may be less effective than Liptor. Zocor uses a lipid reducing agent to reduce Low Density Cholesterol.

Side effects of lipitor vs. zocor

Lipitor has minimal side effects including upset stomach, gas, heartburn, change of taste, diarrhea, constipation, skin rash, headache, dizziness or blurred vision that may occur the first few days as your body adjusts to the medication. Zocor also has similar side effects,if any.

Recommended dosage of zocor vs. lipitor

The recommended starting dose for Lipitor is 10 or 20 mg once daily depending on the condition of the patient. The recommended starting dose for Zocor is 10 mg once a day in the evening.

Drug Interactions of lipitor and zocor

Lipitor may be used in combination with a bile acid binding resin for additive effect. Zocor is effective alone or when used concomitantly with bile-acid sequestrants.

Used with

Both Lipitor and Zocor should be combined with health, diet and exercise. This can assist in a reduction of blood pressure and reduced risk of heart attack significantly.

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