The active ingredient in OxyContin is oxycodone but OxyContin (a brand name derived from "oxycodone continuous") has a time-release mechanism, which means the drug is released in the body over a period of time and patients have to take the drug less often. Regular oxycodone is an immediate-release drug, an opiod narcotic painkiller used to treat moderate to severe pain.

Comparison chart

OxyContin versus Oxycodone comparison chart
Edit this comparison chartOxyContinOxycodone
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Dosage 10mg every 12 hours initially 2.5mg to 10mg orally every 4 to 6 hours, except 12-hour controlled release
Active ingredient Oxycodone Oxycodone
Form Time release Liquid, tablet (both controlled release and immediate release), capsule
Side effects Include nausea, vomiting, constipation, loss of appetite, dizziness, headache, tiredness, dry mouth, sweating and itching Nausea, vomiting, constipation, loss of appetite, dizziness, headache, tiredness, dry mouth, sweating and itching
Use Relief of moderate to severe pain Relief of moderate to severe pain
Overdose Potentially fatal. Same symptoms as oxycodone. Greater risk of overdose Potentially fatal. Symptoms include extreme drowsiness, muscle weakness, confusion, clammy skin, shallow breathing, fainting and coma
Cost $87.78 per month with insurance 120 tablets of generic Percocet (5mg oxycodone + 325mg acetaminophen) is between $23 and $73.
Pregnancy Safe for pregnancy; not safe for breastfeeding Category B drug in U.S. — may be prescribed if benefit to mother outweighs risk to fetus; not recommended while breastfeeding. Animal reproduction studies have not found adverse effects. Category C drug in Australia.

Usage

Oxycodone is used to treat chronic moderate to severe pain, as well as managing breakthrough or acute excessive pain in patients who are treated for chronic pain. OxyContin has similar pain-killing effects but it's used to treat chronic pain. OxyContin is not effective for immediate pain relief (for example in an emergency room).

Dosage

The initial adult dose of oxycodone is 5mg to 15mg taken orally every 4 to 6 hours. This can be increased up to 30mg every 4 hours.

Children who weigh over 50kg can take 5mg of oxycodone every 6 hours, which may be raised to 10mg every 3 to 4 hours over time.

OxyContin is only available in time-release form. Its initial dosage is 10mg every 12 hours, increasing to up to 640mg per day in patients with cancer pain. The average daily dose is 105mg per day.

Which is Stronger - OxyContin or Oxycodone?

This is a bit of a trick question because the active ingredient in OxyContin is oxycodone. However, oxycodone immediate release (IR) will by definition be "stronger" than a continuous release (CR) formulation that is absorbed over a period of time.

Warnings

Oxycodone and OxyContin should not be combined with alcohol, as this can lead to death. It should also not be combined with sedatives, tranquilizers, sleeping pills or muscle relaxers.

Efficacy

A study by the NCBI suggests that oxycodone and OxyContin are equally effective in treating moderate to severe chronic back pain. Specifically, the study concluded that

Controlled-release oxycodone given every 12 hours was comparable with immediate-release oxycodone given four times daily in efficacy and safety, and it provides convenient, twice-daily, around-the-clock treatment for selected patients with persistent back pain that is inadequately controlled by nonopioids or as-needed opioid therapy.

Other studies have focused on cancer-related pain and reached the same conclusion — immediate-release oxycodone is as effective as controlled-release OxyContin. A 2001 study echoed what a prior study in 1998 concluded:

CR oxycodone [i.e., OxyContin] every 12 hours was as effective as IR oxycodone four times daily in managing moderate to severe cancer-related pain and was associated with fewer reports of adverse events.

How long does OxyContin's pain relief last?

When Purdue launched OxyContin, the pharmaceutical company made the claim that one dose of OxyContin relieves pain for 12 hours, which is roughly twice as long as generic medications. But an LA Times investigation found that the claim is misleading and false because drug wears off early for many people.

To combat this phenomenon of the drug wearing off earlier, doctors can either increase the frequency or the dosage of the drug. The LA Times alleged in its reporting that

Purdue tells doctors to prescribe stronger doses, not more frequent ones, when patients complain that OxyContin doesn’t last 12 hours. That approach creates risks of its own. Research shows that the more potent the dose of an opioid such as OxyContin, the greater the possibility of overdose and death.

Side Effects

Side effects of oxycodone — and OxyContin — include nausea, vomiting, constipation, loss of appetite, dizziness, headache, tiredness, dry mouth, sweating and itching.

All opioids have well-known side effects including

respiratory depression, sedation, constipation, and nausea; inconsistent improvement in functioning; opioid-induced hyperalgesia; adverse hormonal and immune effects of long-term opioid treatment; a high incidence of prescription opioid abuse behaviors; and an ill-defined and unclarified risk of iatrogenic addiction.[1]
Side effects of oxycodone. Red denotes more serious effects, requiring immediate contact with health provider.
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Side effects of oxycodone. Red denotes more serious effects, requiring immediate contact with health provider.

Risk of Abuse and Addiction

More than 7 million Americans have abused OxyContin, according to the National Survey on Drug Use and Health.

In his research paper The Promotion and Marketing of OxyContin: Commercial Triumph, Public Health Tragedy, Dr. Art Van Zee writes that Purdue, the manufacturer of OxyContin, systematically and deliberately underrepresented the risk of addiction with OxyContin in an effort to boost sales, especially for non-cancer-related chronic pain. In 2007, Purdue and 3 of its executives pled guilty to criminal charges of misbranding OxyContin by claiming that it was less addictive and less subject to abuse and diversion than other opioids. They were fined $634 million.

Prescription drug abuse of opioids like oxycodone is now more common than cocaine or heroin. When an OxyContin pill is crushed, up to 68% of the opioid (oxycodone) can be extracted from it. Drug abusers crush the OxyContin tablet and consume it by inhaling, swallowing or injecting it. This results in an intense high.

Cost

Everydayhealth reports that oxycodone costs, on average, $18.12 per month for those with insurance. OxyContin costs an average of $87.78 per month with insurance. Oxycodone is a generic active ingredient and there are many manufacturers that sell this drug. On the other hand OxyContin is a brand name drug by Purdue Pharma and like all brand name drugs costs significantly more than generics.

Pregnancy

Oxycodone and OxyContin are FDA pregnancy category B and so are not expected to harm an unborn baby. You should not breast feed while taking oxycodone or OxyContin.

Overdose

Overdose symptoms of oxycodone include extreme drowsiness, muscle weakness, confusion, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, fainting and coma. Overdose can be fatal.

OxyContin has the same overdose symptoms. However, the danger of overdose is more significant in OxyContin than in oxycodone, as there are more milligrams of oxycodone per pill. If OxyContin is chewed, it can release 12 hours worth of medicine in a few minutes.

References

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