Although there might be uncountable differences between 'U' & 'Me', let us look at the grammatical difference between the 2 pronouns 'you' and 'me'

Comparison chart

Me versus You comparison chart
Edit this comparison chartMeYou
Pronoun First person Second person
Example This book belongs to me. You have a beautiful house.

Types of Pronouns

Personal pronouns are divided into three groups called persons: First Person, Second Person and Third Person.

First person is the person speaking:

    I, we
    me, us
    my, mine, our, ours 

Second person is the person spoken to:

    you, your, yours

Third person is the person or thing spoken about:

    he, she, it
    his, her, hers, its
    him, her, it
    they, them, their, theirs

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"Me vs You." Diffen.com. Diffen LLC, n.d. Web. 21 Jul 2018. < >