When choosing infant formula, parents usually decide based on the nutrition, safety record, range of products, availability and prices. This is an unbiased comparison of Similac and Enfamil, the two largest baby formula manufacturers, on these parameters.

Comparison chart

Enfamil versus Similac comparison chart
Edit this comparison chartEnfamilSimilac
  • current rating is 3.02/5
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(128 ratings)
  • current rating is 3.12/5
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(100 ratings)
Company Mead Johnson Abbott Laboratories
Products for pregnant women Expecta R Lipil – support brain development of baby Similac Prenatal
Formula for overall infant development Enfamil R Premium Similac Advance, Similac SimplySmart
Formula to help infants feel full longer Enfamil R Restfull None
Formula to reduce fussiness and gas Enfamil R. Gentlease R Similac Sensitive
Formula to reduce spit up Enfamil A. R. Similac for Spit-Up
Formula to manage colic Nutramigen R with Enflora LGG Similar Expert Care Alimentum
Soy-based, milk-free formula Enfamil R Prosobee Similac Soy Isomil
Formula for premature or low birth weight infants Enfamil R EnfaCare and Enfamil R Premature Similac Expert Care NeoSure
Formula to fortify breast milk Enfamil R Human Milk Fortifier None
Formula for infants with trouble absorbing fat Pregestimil R None
Formula for cow milk protein allergy Nutramigen R AA Similac Expert Care Alimentum
Supplemental vitamin D for breastfed infants Enfamil R D-Vi-Sol Drops None
Vitamin A, C and D for breastfed infants Enfamil R Tri-Vi-Sol None
Formula to replace electrolytes and water Enfamil R Enfalyte None
Formula to provide vitamins during growth spurts Enfamil R Poly-Vi-Sol with Iron Drops Similac Go & Grow
Formula with supplemental iron Enfamil R Fer-In-Sol Drops None
Formula to treat diarrhea None Similac Expert Care for Diarrhea
Products for toddlers Yes Yes
Cost Approx. $25 Approx. $25
Infant drinking from a bottle

Products Available

Enfamil offers a wide range of formulas. Expecta R Lipil is for pregnant women, and supports baby eye and brain development during pregnancy. 16 products are available for infants between 0 and 1 years, including Enfamil R Premium (supports overall development), Enfamil R Restfull (helps infants feel full longer), and Enfamil R EnfaCare (for premature infants). Enfamil has 3 brands for todders age 10 to 36 months: Enfagrow Gentlease R Next Step, Enfagrow Soy Next Step, and Enfagrow Premium Next Step. It also has 1 product for toddlers age 1 to 3 years: Enfagros Premium Flavors.

Similac also offers a wide range of products. Similac Prenatal provides vitamins, minerals and DHA for pregnant women. They offer 11 products for infants, include Similac Advance, Similac Sensitive and Similac Expert Care NeoSure. They also have a range for toddlers to ensure they receive balanced nutrition.

Types of Infant formula

Both Enfamil and Similac are available in various forms like milk based, soy based, (in case there's a milk protein allergy) iron fortified etc.


The nutritional value of Enfamil varies depending on the product. Enfamil PREMIUM formula for newborns has 2.1g of protein, 5.3g of fat, 11.2g of carbohydrates, 860 mg of linoleic acid, 300IU of vitamin A, 75 IU of vitamin D, 16 mcg of folic acid and 17mg of DHA (docosahexaenoic acid) per 5 fluid ounces.

The nutritional value of Similac also varies depending on the product. Similac Advance has 2.07g of protein, 5.4g of fat, 11.2g of carbohydrate, 1000mg of linoleic acid, 300 IU of vitamin A, 75 IU of vitamin D, 15 mcg of folic acid, and an unspecified amount of DHA per 5 fluid ounces.


Enfamil products vary in price, but they cost approximately $25 per 23.2 oz.

Similac products also vary in price, but standard formula costs approximately $25 per 23.2 oz.

Both Enfamil and Similac have a storefront on Amazon.com, and the current prices for their products can be found on Amazon's website.


Availability of Enfamil products varies by country. They are available in North and South America, Europe, and East and South-East Asia.

Similac is sold in the United State, Canada, the Caribbean, Ireland, Pakistan and other countries.

In the United States, both Enfamil and Similac are sold by all major retailers like WalMart, Costco (limited variety) etc. as well as online retailers like Amazon.com and on the product websites enfamil.com / similac.com.

Safety Recall Incidents

In December 2011, Walmart pulled a batch of Enfamil infant formula from stores after a newborn boy in Missouri died from a rare bacterial infection. However, the FDA later said this was unnecessary and that there was no trace of the bacteria in the products.

In 2010, Similac voluntarily recalled certain product lines over fears that they had been infected by beetles and their larvae. The company stressed that the health risk was not serious.


While there are several options available for both Enfamil and Similac, viz.. powder vs concentrated liquid vs ready to drink, milk or soy based etc. the following video provides some general guidelines in choosing a baby formula:


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